Guy Mountfort, 1905-2003

Lucky Guy Knife Assault

We reported a young male with knife assault to his chest. He was transferred to the hospital without manipulating the knife. He was completely conscious and had sinus tachycardia and regular breathing. Emergency thoracotomy was performed and the knife was removed. No organ was damaged. This case presentation showed that in this kind of trauma, it is mandatory not to manipulate the penetrating f...

Dmd059121 1890..1905

Subcutaneous injection is an important route of administration for therapeutic proteins that provides several advantages over other modes of parenteral delivery. Despite extensive clinical use, the exact mechanism underlying subcutaneous absorption of proteins is not completely understood, and the accuracy of prediction of absorption of biotherapeutics in humans remains unsatisfactory. This rev...

Dmd065763 1905..1916

Montelukast has been recommended as a selective in vitro and in vivo probe of cytochrome P450 (P450) CYP2C8 activity, but its selectivity toward this enzyme remains unclear. We performed detailed characterization of montelukast metabolism in vitro using human liver microsomes (HLMs), expressed P450s, and uridine 59-diphospho-glucuronosyltransferases (UGTs). Kinetic and inhibition experiments pe...

Phoebus A. Levene, 1905

Can you follow that guy?

The problem of tracking moving objects or human beings is a challenging problem in mobile robotics. Knowledge about the position of moving subjects can be used both to improve the behavior of the robotic system, and to perform tasks of monitoring or following. Different methodologies have been applied in literature, using different sensors and techniques for addressing this problem. In this pap...